{"id":3149,"date":"2024-08-22T11:44:57","date_gmt":"2024-08-22T14:44:57","guid":{"rendered":"https:\/\/drluizgustavotorres.com.br\/?p=3149"},"modified":"2024-08-23T12:24:04","modified_gmt":"2024-08-23T15:24:04","slug":"a-pesquisa-de-mutacao-e-toda-igual","status":"publish","type":"post","link":"https:\/\/drluizgustavotorres.com.br\/pt\/a-pesquisa-de-mutacao-e-toda-igual\/","title":{"rendered":"A Pesquisa de Muta\u00e7\u00e3o Gen\u00e9tica \u00e9 Toda Igual ?"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"3149\" class=\"elementor elementor-3149\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b47ee28 e-flex e-con-boxed e-con e-parent\" data-id=\"b47ee28\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-843f529 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"843f529\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"735\" src=\"https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica-1024x735.webp\" class=\"attachment-large size-large wp-image-3150\" alt=\"\" srcset=\"https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica-1024x735.webp 1024w, https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica-300x215.webp 300w, https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica-768x551.webp 768w, https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica-18x12.webp 18w, https:\/\/drluizgustavotorres.com.br\/wp-content\/uploads\/2024\/08\/Pesquisa-Genetica.webp 1115w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1575b7c e-flex e-con-boxed e-con e-parent\" data-id=\"1575b7c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bbaa7ff elementor-widget elementor-widget-heading\" data-id=\"bbaa7ff\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Impacto das Muta\u00e7\u00f5es Germinativas e Som\u00e1ticas na Personaliza\u00e7\u00e3o da Terapia Oncol\u00f3gica<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-81c4cac e-flex e-con-boxed e-con e-parent\" data-id=\"81c4cac\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8357d1d elementor-widget elementor-widget-text-editor\" data-id=\"8357d1d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><br \/>Na oncologia, as pesquisas de muta\u00e7\u00e3o som\u00e1tica e muta\u00e7\u00e3o germinativa desempenham pap\u00e9is distintos, mas complementares no diagn\u00f3stico e tratamento do c\u00e2ncer. A muta\u00e7\u00e3o som\u00e1tica ocorre em c\u00e9lulas espec\u00edficas durante a vida de uma pessoa, devido a fatores ambientais ou erros na replica\u00e7\u00e3o do DNA. Essas muta\u00e7\u00f5es n\u00e3o s\u00e3o herdadas nem passadas para a descend\u00eancia, mas s\u00e3o cruciais para o desenvolvimento do c\u00e2ncer. J\u00e1 a muta\u00e7\u00e3o germinativa est\u00e1 presente desde o nascimento em todas as c\u00e9lulas do corpo e pode ser transmitida de pais para filhos, aumentando o risco heredit\u00e1rio de desenvolver c\u00e2ncer.<\/p><p>Com rela\u00e7ao as recomenda\u00e7\u00f5es de tratamento, a identifica\u00e7\u00e3o de muta\u00e7\u00f5es som\u00e1ticas permite a personaliza\u00e7\u00e3o da terapia, direcionando o uso de terapias-alvo que atacam especificamente as altera\u00e7\u00f5es gen\u00e9ticas no tumor. Por exemplo, pacientes com c\u00e2ncer de pulm\u00e3o que possuem muta\u00e7\u00f5es no gene EGFR podem se beneficiar de inibidores de tirosina quinase. J\u00e1 para muta\u00e7\u00f5es germinativas, como aquelas nos genes BRCA1 e BRCA2, o tratamento pode incluir tanto terapias espec\u00edficas, como os inibidores de PARP, quanto estrat\u00e9gias preventivas, como a mastectomia profil\u00e1tica ou vigil\u00e2ncia intensiva.<\/p><p>Portanto, a escolha do tratamento depende da natureza da muta\u00e7\u00e3o. Enquanto as muta\u00e7\u00f5es som\u00e1ticas direcionam terapias focadas no tumor espec\u00edfico, as muta\u00e7\u00f5es germinativas exigem uma abordagem mais ampla, que inclui a preven\u00e7\u00e3o e o monitoramento cont\u00ednuo, n\u00e3o s\u00f3 para o paciente, mas tamb\u00e9m para seus familiares, dado o risco heredit\u00e1rio associado.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Impacto das Muta\u00e7\u00f5es Germinativas e Som\u00e1ticas na Personaliza\u00e7\u00e3o da Terapia Oncol\u00f3gica Na oncologia, as pesquisas de muta\u00e7\u00e3o som\u00e1tica e muta\u00e7\u00e3o germinativa desempenham pap\u00e9is distintos, mas complementares no diagn\u00f3stico e tratamento do c\u00e2ncer. A muta\u00e7\u00e3o som\u00e1tica ocorre em c\u00e9lulas espec\u00edficas durante a vida de uma pessoa, devido a fatores ambientais ou erros na replica\u00e7\u00e3o do DNA. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":3150,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"cybocfi_hide_featured_image":"","footnotes":""},"categories":[1],"tags":[30,27,28,29],"blocksy_meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/posts\/3149"}],"collection":[{"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/comments?post=3149"}],"version-history":[{"count":14,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/posts\/3149\/revisions"}],"predecessor-version":[{"id":3198,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/posts\/3149\/revisions\/3198"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/media\/3150"}],"wp:attachment":[{"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/media?parent=3149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/categories?post=3149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drluizgustavotorres.com.br\/pt\/wp-json\/wp\/v2\/tags?post=3149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}